Interdisciplinary Pharmacoeconomic Research Concerning the Рharmacotherapy of Alcoholic Hepatitis in Conditions of Covid-19 Pandemic




COVID-19, drugs, alcoholic hepatitis, pharmacotherapy, interdisciplinary pharmacoeconomic research


Substantiated the relevance and necessity of the chosen research topic as a result of a review of the scientific literature on the epidemiology and pharmacotherapy of patients with alcoholic hepatitis. Contradictory evidence exists regarding the association between international and national clinical protocols for the management of alcoholic hepatitis in the context of the COVID-19 pandemic. Author undertook the present study to justify the procurement of drugs for patients with alcoholic hepatitis based on pharmacoeconomic calculations for hospitals. This study is based on pharmacoeconomic, organizational and legal, forensic and pharmaceutical approaches to pharmacotherapy with using literature review. Clinical and pharmacological analysis of basic therapy of alcoholic hepatitis was performed. Pharmacoeconomic studies have been conducted. According to the results of the ABC analysis, group A includes one drug (INN Ursodeoxycholic acid). According to the results of VEN analysis, it was proved that one drug (INN Prednizolone) belongs to category V (Vital). This study provides an opportunity to make administrative and managerial decisions in determining the pharmacotherapy of patients with alcoholic hepatitis to improve the use of drugs in hospitals.

Author Biography

Viktoriia Shapovalova, Lugansk State Medical University

Doctor of Pharmaceutical Sciences, Professor, Luhansk State Medical University

Public Organization “Association of Medical and Pharmaceutical Law”


Roberts M. Covid-19: New mutation of Delta variant under close watch in UK. BBC News online. 19.10.2021. URL:

Clive Cookson C., Burn-Murdoch J. New Delta descendant may be more infectious than its ancestor. FT. 18.10.2021. URL:

Dr Fauci on Delta variant: Unvaccinated Americans risk new Covid surge. ВВС. 2021. URL:

COVID-19 dashboard by the Centre for Systems Science and Engineering at John Hopkins University. COVID-19 dashboard by the Centre for Systems Science and Engineering at John Hopkins University. 2021. URL:

Julien J., Ayer T., Tapper E.B. et al. Effect of increased alcohol consumption during COVID-19 pandemic on alcohol-related liver disease: a modeling study. AASLD. 08.12.2021. URL: DOI:

Shapovalova V.A., Zbrozhek S.I., Shapоvalov V.V. et al. Coronavirus disease pandemia 2019: growth of epidemic dangers. Acta scientific pharmaceutical sciences. 2020. Vol. 4. Iss. 7. P. 61–68. URL: DOI:

2nd WHO Forum on alcohol, drugs and addictive behaviours. WHO. 27.06.2019. URL:

Sosin I.K., Chuev Yu.F., Artemchuk A.P. et al. Narcology: national textbook. Kharkiv, Ukraine: Kolegium. 2014. 948 p.

Health Care for All: A Framework for Moving to a Primary Care-Based Health Care System in the United States. AAFP. 19.10.2021. URL:

European centre for disease prevention and control, and European monitoring centre for drugs and drug addiction. Public health guidance on active case finding of communicable diseases in prison settings. Prevention and control of communicable diseases in prison setting. 2018. DOI: 10.2900/619331. URL:

Winters A. C., May F. P., Wang Y. et al. Alcohol use disorder treatment and outcomes among hospitalized adults with alcoholic hepatitis. Drug and Alcohol Dependence Reports. 2021. Vol.1. No.12. Article 100004. URL: DOI:

Alcohol responsible for one in 20 deaths worldwide: WHO. Medicalxpress, september 21, 2018. URL:

Third WHO Forum on Alcohol, Drugs and Addictive Behaviours (FADAB). WHO. 22.06.2021. URL:

Shapovalov V., Diachenko A. Interdisciplinary Forensic and Pharmaceutical Study of Illegal circulation of falsified alcoholic beverages to combat crime and prevent Public Health disorders. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.1. P.1-12. URL: DOI:

Hayduchok I., Shapovalova V., Ishcheikin K. et al. Pharmaeconomic approaches for pharmacotherapy of Rheumatoid arthritis. Likars’ka Sprava. 2021. No. 1–2. P.70-79. URL: DOI:

Chuiev Y., Shapovalova V. Integrated ABC/VEN-analysis of drug prescriptions in pharmacotherapeutic schemes for relief of drunken forms of alcohol dependence. SSP Modern Pharmacy and Medicine. 2022. Vol.2. Nо.1. P.1-14. URL: DOI:

Chuiev Y., Shapovalova V. Interdisciplinary pharmacoeconomic study of pharmacotherapy of cupping of drunk forms of alcohol dependence: clinical and pharmacological, organizational, legal and marketing experiment. SSP Modern Pharmacy and Medicine. 2021. Vol. 1. N. 2. P. 1–12. URL: DOI:

Shapovalova V. Alcoholic Hepatitis: An experimental meta-analysis. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.1. P.1-11. DOI: DOI:

Snow J. United States agency for international development. Logistics Indicators Assessment Tool. 2005. Arlington, VA.: John Snow, Inc. / DELIVER.

ATC-classification. Compendium. URL:

Management sciences for Health. Managing medicines selection. In MDS-3: Managing access to Medicines and Health technologies. Arlington, VA, USA: Management Sciences for Health (MSH), 2012. URL:

Devnani M., Gupta A., Nigan R. ABC and VED Analysis of the Pharmacy store of a tertiary care teaching, research and referral healthcare institute of India. Journal Young Pharmacy. 2010. Vol.2. No.2. P.201-205. URL: DOI:

Fact Sheet: The American rescue plan: reduces health care costs, expands access to insurance coverage and addresses health care disparities. 12.05.2021. URL:

CMS Completes historic price transparency initiative. 29.10.2020. URL:

Order of the Ministry of Health of Ukraine “On approval of the twelfth issue of the State formulary of medicines and ensuring its availability”. 06.05.2020 No. 1075. URL:

National list of basic medicines. Resolution of the Cabinet of Ministers of Ukraine. 25.03.2009 No. 333. URL:




How to Cite

Shapovalova, V. (2023). Interdisciplinary Pharmacoeconomic Research Concerning the Рharmacotherapy of Alcoholic Hepatitis in Conditions of Covid-19 Pandemic. SSP Modern Pharmacy and Medicine, 3(2), 1–10.



Health Sciences