Monkeypox Virus – New Challenges of Modernity: Experimental Organizational and Legal, Clinical and Pharmacological Studies

Authors

DOI:

https://doi.org/10.53933/sspmpm.v2i3.54

Keywords:

monkeypox virus, organizational and legal, clinical and pharmacological studies, evidence-based medicine, evidence-based pharmacy, epidemiology, risks, monkeypox symptoms, monkeypox vaccination, monkeypox recommendations

Abstract

The article presents the results of the research for the new challenges of today regarding the incidence of monkeypox virus using organizational and legal, clinical and pharmacological approaches to analyze epidemiology, risks, symptoms, vaccination opportunities, recommendations for detection, pharmacotherapy and prevention. Complex experimental organizational and legal, clinical a n d pharmacological study was conducted. The research was conducted on the basis of the disciplines of healthcare organization, pharmacy organization and management, forensic pharmacy, clinical pharmacy, management for different groups of patients and was based on the principles of evidence-based medicine, evidence-based pharmacy. Issues of epidemiology, risks, symptoms, vaccination of monkeypox disease were studied. Recommendations of the WHO and scientific circles concerning the effectiveness of detection, pharmacotherapy, and prevention of monkeypox were analyzed.

Author Biography

Viktoriia Shapovalova, Kharkiv Medical Academy of Postgraduate Education

E-mail: pharm_law@ukr.net

References

Universal Declaration of Human Rights. UN. 28.06.2022. URL: https://www.un.org/en/about-us/universal-declaration-of-human-rights.

Human Rights Defence. NHC. 28.06.2022. URL: https://www.nhc.nl/programmes/human-rights-defence/?gclid=EAIaIQobChMIlOe5sszP-AIVldwYCh1TxQPXEAAYBCAAEgKfZ_D_BwE.

Shapovalov V. (Jr.), Zbrozhek S., Gudzenko A. et al. Organizational and legal analysis of the pharmaceutical provision for the most common diseases of society. International Journal of Pharmaceutical Sciences Review and Research. 2018. Vol. 51. N. 1. P. 118-124. URL: http://globalresearchonline.net/journalcontents/v51-1/18.pdf.

Zbrozgek S. Reform of the healthcare system as a basis for streamlining the organization of circulation and availability of medicines for patients in the context of the COVID-19 pandemic. SSP Modern Pharmacy and Medicine. 2021. Vol. 1. No. 2. P. 1-32. URL: https://doi.org/10.53933/sspmpm.v1i2.31. DOI: https://doi.org/10.53933/sspmpm.v1i2.31

Shapovalova V. The ICD-11 for the twenty-first century: the first view from the organizational, legal, clinical and pharmacological aspects. SSP Modern Pharmacy and Medicine. 2022. Vol.2. N.1. P.1-13. URL: https://doi.org/10.53933/sspmpm.v2i1.37. DOI: https://doi.org/10.53933/sspmpm.v2i1.37

Shapovalov V.V. (Jr.), Shapovalova V.A., Shapovalov V.V. Development of forensic and pharmaceutical researches within the organization of pharmaceutical business, drug technology and pharmaceutical law in Ukraine concerning the turnover of controlled drugs and substances. Health of Society. 2021. Vol. 10. N. 3. P. 98-106. DOI: https://doi.org/10.22141/2306-2436.10.3.2021.246351. DOI: https://doi.org/10.22141/2306-2436.10.3.2021.246351

Shapovalov V. (Jr.), Gudzenko А., Komar L. et al. Concerning the importance of forensic and pharmaceutical researches to improve patients’ accessibility to medicines. Pharmacia. 2017. Vol. 65. N.2. P.23–29. URL: http://bsphs.org/wp-content/uploads/2017/07/Shapovalov.pdf.

McGill L. Patient safety: a European Union priority. Clin Med (Lond). 2009. Vol. 9. N.2. Р.136-139. doi: 10.7861/clinmedicine.9-2-136. URL: https://pubmed.ncbi.nlm.nih.gov/19435118/. DOI: https://doi.org/10.7861/clinmedicine.9-2-136

Constitution of Ukraine. Verkovna Rada of Ukraine. URL: https://zakon.rada.gov.ua/laws/show/254%D0%BA/96-%D0%B2%D1%80#Text).

Закон України «Основи законодавства України про охорону здоров'я». Відомості Верховної Ради України (ВВР). 1993. № 4, ст.19. URL: https://zakon.rada.gov.ua/laws/show/2801-12#Text.

Shapovalova V.A., Zbrozhek S.I., Shapоvalov V.V. et al. Coronavirus disease pandemia 2019: growth of epidemic dangers. Acta scientific pharmaceutical sciences. 2020. Vol.4. Iss.7. P.61–68. URL: https://www.actascientific.com/ASPS/ASPS-04-0559.php. DOI: https://doi.org/10.31080/ASPS.2020.04.0559

Hayduchok І. Рharmacotherapy of systemic autoimmune diseases in conditions of the COVID-19 pandemic: innovative experimental study. Science Review. 2021. Vol. 3. No. 38. P. 1-7. DOI:10.31435/rsglobal_sr/30072021/7619. DOI: https://doi.org/10.31435/rsglobal_sr/30072021/7619

Hayduchok І., Shapovalov V. Covid-19: multidisciplinary researches of forensic and pharmaceutical risks and causal relationships of unqualified medical care for patients during pandemic. 2022. SSP Modern Law and Practice. Vol.2. N.1. P.1-25. URL: https://doi.org/10.53933/sspmlp.v2i1.39. DOI: https://doi.org/10.53933/sspmlp.v2i2.51

COVID pandemic fuelling major increase in drug use worldwide: UN report. United Nations. URL: https://news.un.org/en/story/2021/06/1094672.

Booster vaccination: why it is so important, despite the fact that vaccinated Israel continues to get sick. TSN. 03.12.2021. URL: https://tsn.ua/svit/busterne-scheplennya-chomu-vono-duzhe-vazhlive-popri-te-scho-vakcinovaniy-izrayil-prodovzhuye-hvoriti-1922848.html.

Shapovalova V.A., Shapovalov V.V. The clinical efficacy of the combined drug agent Valcophen in children. Likars'ka sprava. 1999. N.1. P.124–126.

Shapovalova V.O., Mykhailov V.S., Shapovalov V.V. The characteristics of the development of cataleptic phenomena during the action of a new Ukrainian neuroleptic--a butyrophenone derivative--in experiments on mice. Fiziolohichnyi zhurnal. 1999. Vol.45. N.3. P 114–117.

Shapovalova V.O., Shapovalov V.V. Spasmophilia in children and the anticonvulsant properties of a new Ukrainian preparation containing a pyrimidine derivative. Fiziolohichnyi zhurnal. 1998. Vol.44. N.5-6. P. 102–105. DOI: https://doi.org/10.1049/ir:19980309

Shapovalova V.O., Chernykh V.P. The physiological properties of the action of a new analgesic and antipyretic preparation. Fiziolohichnyi zhurnal. 1997. Vol.43. N.1-2. P. 117–121.

Shapovalov V.V. (Jr.), Zbrozhek S.I., Shapovalova V.O. et al. Organizational and legal evaluation of availability of medicines’ circulation for cancer patients Pharmacia. 2018. Vol. 65. N. 2. P. 17-22. URL: http://bsphs.org/?magasine=organizational-and-legal-evaluation-of-availability-of-medicines-circulation-for-cancer-patients.

Shapovalov V., Butko L., Shapovalov V. Organizational and legal study of quarantine restrictions in the spread of coronavirus disease in Ukraine. SSP Modern Pharmacy and Medicine. 2021. Vol. 1. N. 2. P. 1–12. URL: https://doi.org/10.53933/sspmpm.v1i2.23. DOI: https://doi.org/10.53933/sspmpm.v1i2.23

Hayduchok I. G. Innovation approaches to pharmacotherapy of systemic autoimmune diseases in the conditions of the COVID-19 pandemic. Likars’ka Sprava. 2020. N. 7–8. P. 64-74. doi: 10.31640/JVD.7-8.2020 (8). DOI: https://doi.org/10.31640/JVD.7-8.2020(8)

COVID pandemic fuelling major increase in drug use worldwide: UN report. United Nations. URL: https://news.un.org/en/story/2021/06/1094672.

UN analysis shows link between lack of vaccine equity and widening poverty gap. UN. 28.05.2022. URL: https://news.un.org/en/story/2022/03/1114762.

Government responses to COVID-19: Lessons on gender equality for a world in turmoil. UNwomen. 28.05.2022. URL: https://www.unwomen.org/en/digital-library/publications/2022/06/government-responses-to-covid-19-lessons-on-gender-equality-for-a-world-in-turmoil?gclid=EAIaIQobChMI8s36-83P-AIVMI1oCR3kSgheEAAYAiAAEgLcS_D_BwE.

Monkeypox. WHO. 19.05.2022. URL: https://www.who.int/news-room/fact-sheets/detail/monkeypox.

Chuiev Y., Shapovalova V. Interdisciplinary pharmacoeconomic study of pharmacotherapy of cupping of drunk forms of alcohol dependence: clinical and pharmacological, organizational, legal and marketing experiment. SSP Modern Pharmacy and Medicine. 2021. Vol. 1. N. 2. P. 1–12. URL: https://doi.org/10.53933/sspmpm.v1i2.24. DOI: https://doi.org/10.53933/sspmpm.v1i2.24

Shapovalov V.V. (Jr.), Shapovalova V.A., Shapovalov V.V. Forensic and pharmaceutical research on the impact of drugs on the safety, life and health of road users within the organization of pharmaceutical business, drug technology, pharmaceutical and medical law in Ukraine. Health of Society. 2021. Vol. 10. N. 4. P. 127-132. DOI: https://doi.org/10.22141/2306-2436.10.4.2021.246355. DOI: https://doi.org/10.22141/2306-2436.10.4.2021.246355

Shapovalova V., Zakharchenko I. Organizational and legal approaches to reforming of the law enforcement system of Ukraine: illegal circulation of psychoactive substances and addictive dependence. 2021. SSP Modern Law and Practice. Vol. 1. N.1. P.1–22. URL: https://doi.org/10.53933/sspmlp.v1i1.20. DOI: https://doi.org/10.53933/sspmlp.v1i1.20

Shapovalov (Jr.) V., Gudzenko A., Shapovalova V. et al. Forensic and pharmaceutical analysis of addictive morbidity because of the use of narcotic psychoactive substances in Ukraine (retrospective aspect). International Journal of Pharmaceutical Sciences and Research. 2018. Vol. 3. Is.3. July 2018. P.22-25. URL: http://www.pharmacyjournal.net/archives/2018/vol3/issue3.

Shapovalov V. (Jr.), Gudzenko A., Shapovalova V. et. el. Forensic and pharmaceutical study of the presence of a causal link between the degree of alcohol abuse and qualification level of the respondents. Pharmacia. 2017. Vol. 66. N. 3. Р. 31–39. URL: http://bsphs.org/wp-content/uploads/2017/11/Shapovalov.pdf.

Tukhar I., Shapovalova V., Shapovalov V. et al. Pharmacological view on the problem of comorbidity in the pharmacotherapy of chronic pancreatitis. Science Review. Vol. 3. No. 38. P. 1-5. DOI: 10.31435/rsglobal_sr/30072021/7591. DOI: https://doi.org/10.31435/rsglobal_sr/30072021/7591

Shapovalova V.O., Zbrozhek S.I., Shapovalov V.V. (Jr.) et al. Content analysis of pharmacies in Ukraine, which produce extemporaneous drugs. Public health. 2017. T.6. N.3–4. P.77–83. DOI: 10.22141/2306-2436.6.3.2017.123498. DOI: https://doi.org/10.22141/2306-2436.6.3.2017.123498

Shapovalova V. An Innovative multidisciplinary study of the availability of coronavirus vaccines in the world. SSP Modern Pharmacy and Medicine. 2022. Vol.2. N.2. P.1–17 URL: https://doi.org/10.53933/sspmpm.v2i2.45. DOI: https://doi.org/10.53933/sspmpm.v2i2.45

Shapovalov V.V. (Jr), Zbrozhek S.I., Shapovalova V.O. et al. Organizational and legal regulation procedure for circulation of extemporal medicines based on pharmaceutical law. Annals of Mechnikov Institute. 2017. N.4. P. 33-37. URL: http://www.imiamn.org.ua/journal/4_2017/zmist4_2017.html.

Shapovalov (Jr.) V., Gudzenko A., Shapovalova V. et al. Forensic and pharmaceutical study of the presence of a causal link between the degree of alcohol abuse and qualification level of the respondents. Pharmacia. 2017. Vol.66. N.3. Р.31–39. URL: http://bsphs.org/wp-content/uploads/2017/11/Shapovalov.pdf.

Osyntseva A. Forensic and evidence pharmacy: features of medical, pharmacological and pharmaceutical correction. Actual problems of medicine and pharmacy. 2020. Vol.1. N.1-2. URL: https://apmplmi.com/index.php/apmp/article/view/19.

Zbrozhek S. Medical and pharmaceutical legislation: normative and legal regulation of healthcare specialists’ activities in Finland. SSP Modern Pharmacy and Medicine. 2021. Vol.1. N.1. P.1-8. URL: https://doi.org/10.53933/sspmpm.v1i1.5. DOI: https://doi.org/10.53933/sspmpm.v1i1.5

Multi-country monkeypox outbreak: situation update. WHO. 17 June 2022. URL: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON393.

Epidemiological update: Monkeypox multi-country outbreak. ECDC. 15.06.2022. URL: https://www.ecdc.europa.eu/en/news-events/epidemiological-update-monkeypox-multi-country-outbreak-15-june.

Monkeypox cases reported in UK and Portugal. ECDC. 19.05.2022. URL: https://www.ecdc.europa.eu/en/news-events/monkeypox-cases-reported-uk-and-portugal#:~:text=All%20cases%20reported%20on%2016,also%20reported%20eight%20suspected%20cases.

Freud O. Mysterious monkeypox is spreading in more and more countries. DW. 20.05.2022. URL: https://www.dw.com/uk/taiemnycha-mavpiacha-vispa-shyrytsia-u-vse-bilshii-kilkosti-krain/a-61880059.

Multi-country monkeypox outbreak in non-endemic countries. WHO. 21.05.2022. URL: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON3.

Monkeypox: What we know about the virus as the WHO considers if the outbreak is an 'emergency'. Euronews. 23.06.2022. URL: https://www.euronews.com/next/2022/06/23/monkeypox-what-we-know-so-far-about-the-smallpox-like-virus-detected-in-the-uk.

There is no significant risk of the spread of monkeypox in Ukraine – opinion. Interfax–Ukraine. 15.06.2022. URL: https://interfax.com.ua/news/pharmacy/839347.html.

The chances of the spread of monkeypox in the territory of Ukraine are very small – chief sanitary doctor Kuzin. Interfax-Ukraine. 25.05.2022. URL: https://interfax.com.ua/news/pharmacy/834455.html.

Monkey pox will most likely reach Ukraine - sanlikar. Analytical portal «Slovo i Dilo». 28.05.2022. URL: https://www.slovoidilo.ua/2022/05/28/novyna/suspilstvo/vispa-mavp-shvydshe-vse-dijde-ukrayiny-sanlikar.

Ileyemi M. Monkeypox: Report says infection causes blindness, as global cases surpass 2,000. Premium Times. 20.06.2022. URL: https://www.premiumtimesng.com/news/top-news/538172-monkeypox-report-says-infection-causes-blindness-as-global-cases-surpass-2000.html.

Kluge H. P. Monkeypox: urgently tackling a neglected disease, together. WHO. 15 June 2022. URL: https://www.who.int/europe/news/item/15-06-2022-statement---monkeypox--urgently-tackling-a-neglected-disease--together. DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.24.2200482

Rapid risk assessment: Monkeypox cases in the UK imported by travellers returning from Nigeria. ECDC. 2018. URL: https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-monkeypox-cases-uk-imported-travellers-returning-nigeria.

Joi P. Five things you need to know about monkeypox. VaccinesWork. 17.05.2022. URL: https://www.gavi.org/vaccineswork/five-things-you-need-know-about monkeypox?gclid=Cj0KCQjwhqaVBhCxARIsAHK1tiNJOUVcSJ1LiHMT6GS1mlWATN1IyMwH1AWd3WLXLkkDzAxzZ6QCZ_kaAoO_EALw_wcB.

Belgium becomes the first country to impose quarantine on monkeypox patients. TOneTO. 24.05.2022. URL: https://toneto.net/news/kultura/belgiya-pervoy-obyazala-zaragennih-obezyaney-ospoy-soblyudat-karantin.

Bunge E., Hoet B., Chen L. et al. Changing epidemiology of monkeypox in humans – a potential threat? Systematic review. PLoS Negl Trop Dis. 2022. Vol.16. N.2. P.e0010141. URL: https://doi.org/10.1371/journal.pntd.0010141. DOI: https://doi.org/10.1371/journal.pntd.0010141

Factsheet for health professionals on monkeypox. ECDC. 14 June 2022. URL: https://www.ecdc.europa.eu/en/all-topics-z/monkeypox/factsheet-health-professionals.

Editor. Monkeypox: a neglected old foe. The Lancet. 01.06.2022. Vol.22. Iss. 7. P.913. URL:https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00377-2/fulltext. DOI: https://doi.org/10.1016/S1473-3099(22)00377-2

DNCEZID. Monkeypox and Smallpox Vaccine Guidance. CDC. 02.06.2022. URL: https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html.

Multi-country monkeypox outbreak: situation update. WHO. 17.06.2022. URL: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON393.

Keersmaecker De S., Favalli V. HERA secures vaccines for EU Member states in response to the monkeypox outbreaks. EC. 14.06.2022. URL: https://ec.europa.eu/commission/presscorner/detail/en/ip_22_3674.

Opening remarks by the Director-General of WHO at the press briefing on COVID-19. WHO. 14.06.2022 г. URL: https://www.who.int/ru/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-covid-19-media-briefing--14-june-2022.

Coronavirus 2.0: WHO has declared an outbreak of monkeypox a pandemic.23.06. 2022. DSNews. URL: https://www.dsnews.ua/world/koronavirus-2-0-vooz-ogolosila-spalah-vispi-mavp-pandemiyeyu-23062022-461510.

WHN declares a dangerous monkey a pandemic. WHN. URL: https://www.worldhealthnetwork.global.

Declaring monkeypox a global pandemic. WHN. 22.06.2022. URL: https://www.worldhealthnetwork.global/monkeypoxdeclaration. DOI: https://doi.org/10.51627/PGHR.2022.10.00117

Ileyemi M. Monkeypox: UK deploys smallpox vaccines as cases spread in Europe. Premium Times. 20.05. 2022. URL: https://www.premiumtimesng.com/news/more-news/531316-monkeypox-uk-deploys-smallpox-vaccines-as-cases-spread-in-europe.html.

Hugh A., Gould S., Hine P. et al. Clinical feature and management of human monkeypox: retrospective observational study in the UK. The Lancet. Online First. 24.05.2022. URL: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00228-6/fulltext.

Alimuddin Z., Valderias S., Haider N. et al. Mankeypox outbreaks outside endemic regions: scientific and social priorities. The Lancet. 2022. Vol.22. Iss.7. P.929-931. URL: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00354-1/fulltext. DOI: https://doi.org/10.1016/S1473-3099(22)00354-1

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2022-07-13

How to Cite

Shapovalova, V. (2022). Monkeypox Virus – New Challenges of Modernity: Experimental Organizational and Legal, Clinical and Pharmacological Studies. SSP Modern Pharmacy and Medicine, 2(3), 1–15. https://doi.org/10.53933/sspmpm.v2i3.54

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Health Sciences