Theoretical and Experimental Approaches to Study of Biological Objects by Mathematical Methods Using the Example of Hormone Production in the Thyroid Gland




biological system, expert systems, thyroid gland, follicular cell, pre-disease, markers of changes, hypothyroidism, correlation portrait, nodal dots


The study of any biological object is a complex process that involves a number of successive stages, one of which tools can be a specially created expert system. It is advisable to present the conclusion about the studied biological object in clear forms of expression – quantitative or binary, which are the results of the practical application of the principles of absorption by some researched factors of others, a compromise between them or the prevailing alternative of the studied properties. The involvement of mathematical technologies in the identification and explanation of the regularities of the activity of biological objects requires the display of the results of their research using a mathematical language. This makes it possible to establish regularities in the course of biological processes and predict their consequences. Since any living system is formed from a large number of elements, the organism has a complex hierarchy of structural and functional levels of organization. A mandatory prerequisite for the activity of a biological system is a variety of states, each of them being characterized by its own characteristics – markers of change, which, according to the degree of completeness of the one state transformation into another, should be divided into markers of primary changes, markers of prevailing majority changes, and markers of final changes. Comprehensive application of the Semi-quantitative analysis of electronograms according to Ryabukha O. (2000) and her method for determining the profiles of hormonopoietic cells’ special capacities (2003) when studying the cytophysiology of the thyroid gland in normal and pathological conditions, it is possible to determine the specific link of the follicular cell’s specialized activity, in which there was a violation of hormonopoiesis, and to assess its intensity. The developed Conceptual apparatus of functional connections between organelles of hormone-producing cells when studying them by the Method of correlation analysis by creating intra- and intersystem correlation portraits reflects the features of mutual influences and interdependencies, which deepens the understanding of the intimate mechanisms of hormonopoiesis.

Author Biography

Olha Ryabukha, Lviv Medical University

MD, PhD in Medical Sciences, Professor, Lviv Medical University, Ukraine


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How to Cite

Ryabukha, O. (2024). Theoretical and Experimental Approaches to Study of Biological Objects by Mathematical Methods Using the Example of Hormone Production in the Thyroid Gland. SSP Modern Pharmacy and Medicine, 4(3), 1–14.



Health Sciences. Medicine